Keloid

I saw one of your article using keloid fibroblasts published in Science.

>>> I saw one of your articles using keloid fibroblasts published in Science.

As I read your article, I thought you seemed more interested in adipocytes than keloid fibroblasts.

>> Correct

>> OR: I read your article and it seems that you are more interested in adipocytes than keloid fibroblasts.

 I wonder if you are still working on keloid fibroblast research.

>> Correct 

 Are you interested in research to induce myofibroblast into normal fibroblast?

>> Correct

In fact, that would be a key to keloid treatment.

>> Correct
 There are many hypotheses for keloid pathogenesis such as increased epithelial mesenchymal transition and inflammation, overactivation of TGF-Smad signaling, cancer cell-like stemness. 

>> There are many hypotheses for keloid pathogenesis, such as increased epithelial mesenchymal transition and inflammation, overactivation of TGF-Smad signaling, and cancer cell-like stemness. 

 As you know, creating a keloid mouse model is very hard and it may not be suitable depending on the condition of the human tissue. Have you ever experienced to made it? 

>>  As you know, creating a keloid mouse model is very hard and it may not be suitable depending on the condition of the human tissue. Have you ever experienced making it? 

>> OR: Creating a keloid mouse model is really hard and it may not be suitable depending on the condition of the human tissue. Have you ever experienced making one? 

 I have been studying about keloid fibroblast. My hypothesis is that keloid fibroblasts will show increased autoinflammation and decreased autophagy. One of my friends is an expert in autophagy. She and I are working together about that.

>> Correct

My hypothesis is that keloid fibroblasts will show increased autoinflammation that can result from overexpression of certain type of inflammatory marker. Various inflammatory cytokines have recently been reported to be increased in keloid tissue. I found some candidate genes from Dr. [Name]’s article yesterday. Do you think this is worth studying if we create conditioned knockout mice with these candidate genes? Please find the attached files.

>> Correct